Northwestern University Feinberg School of Medicine

Department of Pharmacology

Murali  Prakriya, PhD

Murali Prakriya, PhD

Associate Professor of Pharmacology

Contact

312/503-4892

Searle Building Room 8-510
320 E Superior
Chicago IL 60611

Education and Certification

PhD: Washington University, Neuroscience (1997)
Postdoctoral Fellowship: Washington University (1999)
Postdoctoral Fellowship: Stanford University (2004)

Interests

Description of Interests

Research in our laboratory is focused on the molecular and cellular mechanisms of intracellular calcium (Ca2+) signaling. Ca2+ is a ubiquitous intracellular signaling messenger, mediating many essential functions including gene expression, chemotaxis, and neurotransmitter release. Cellular Ca2+ signals generally arise from the opening of Ca2+ permeable ion channels, a diverse family of membrane proteins. We are studying Ca2+ signals arising from the opening of Store-Operated channels (SOCs), a family of plasma membrane Ca2+ channels activated by a decrease in the calcium content of the endoplasmic reticulum (ER). Human patients with mutations in SOCs suffer from a devastating immunodeficiency, underscoring their vital importance for human immunity. We are studying the molecular and cellular mechanisms by which SOCs are activated and the mechanisms by which they regulate gene expression, immune cell function, and the development of neural stem cells.

Interests (Keywords)

Cell Imaging; Cellular Electrophysiology; Immunology; Ion Channels; Neurobiology; Pharmacology; Physiology; Stem Cells

Research and Publications

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