Northwestern University Feinberg School of Medicine
Department of Pharmacology
Paul W Burridge, PhD

Paul W Burridge, PhD

Assistant Professor of Pharmacology

Focus of Work

Bio

We study the application of patient-specific human induced pluripotent stem cells in studying the role of the genome in influencing drug responses, a field known as pharmacogenomics or personalized medicine. Our major effort has been focused on patient-specific responses to chemotherapy agents. We ask the question: what is the genetic reason why some patients have minimal side effects of their cancer treatments, whilst others encounter highly detrimental side effects? These side effects can in...[Read full text]We study the application of patient-specific human induced pluripotent stem cells in studying the role of the genome in influencing drug responses, a field known as pharmacogenomics or personalized medicine. Our major effort has been focused on patient-specific responses to chemotherapy agents. We ask the question: what is the genetic reason why some patients have minimal side effects of their cancer treatments, whilst others encounter highly detrimental side effects? These side effects can include cardiomyopathy (heart failure or arrhythmias), peripheral neuropathy, or hepatotoxicity (liver failure). It is our aim to add to risk-based screening by functionally validating genetic changes that predispose a patient to a specific drug response. We use a combination of next-generation sequencing, automation and robotics, high-throughput drug screening, high-content imaging, tissue engineering, and electrophysiological testing to better understand the mechanisms of drug response and action.[Shorten text]

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Education and Certification

  • PhD: University of Nottingham, UK, Stem Cell Biology (2008)