News and Announcements

In research published in Science Advances, scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington’s disease, an incurable, debilitating illness that causes nerve cells to break down in the brain.

Northwestern Medicine investigators have identified novel genetic mechanisms that regulate blood vessel growth in the retina and may also serve as therapeutic targets for retinal vascular disease, according to findings published in Nature Communications.

Northwestern Medicine scientists have developed a new method of measuring and optimizing the maturation process of cultured heart cells, an approach that will set the future standard for a commonly used cell model in scientific research, according to details published in Cell Reports.

Northwestern Medicine scientists have developed a method to identify and characterize microproteins, a development which opens the door for understanding physiology and disease at a molecular level not possible until now, according to findings published in Nature Communications.

Scientists have discovered a neuronal pathway involved in how the brain encodes the transition to high-intensity fear response behaviors required for survival, according to a study published in Nature.

A new molecular technology capable of binding to mRNA and regulating gene expression may offer a new avenue for treating diseases caused by insufficient protein levels, according to a study published in Nature Communications.

Northwestern Medicine investigators have uncovered new mechanisms by which iron deficiency inhibits cell growth and proliferation in eukaryotic cells, findings that could improve the understanding of cancer growth and the development of targeted cancer therapies.

A new Northwestern Medicine study has discovered a novel therapeutic target and therapeutic agents for older patients with acute respiratory distress syndrome, according to recent findings published in Science Translational Medicine.

Northwestern Medicine scientists have developed a new technique for measuring protein folding stability on an unprecedented scale, according to a new study published in Nature.

Investigators have discovered that a subset of sensory neurons promote osteoarthritis-related joint pain and inflammation, suggesting a new therapeutic target for pain management, according to findings published in Nature Communications.

Investigators led by Barbara Stranger, PhD, associate professor of Pharmacology, developed a guide outlining best practices for studying and testing sex-dependent genetic effects in complex traits and diseases, published in the journal Cell.

Targeting calcium signaling in neurons may represent a promising therapeutic approach for treating a rare form of schizophrenia, according to a Northwestern Medicine study.

A team of Northwestern investigators led by Peter Penzes, PhD, has developed a new therapy that could treat Phelan-McDermid syndrome, a subtype of autism spectrum disorder.

Using machine learning, Northwestern scientists have demonstrated that the protein membrane CD81 interacts with CD44 in promoting tumor cell cluster formation and lung metastasis of triple negative breast cancer.